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T effectors outfox T regulators in autoimmunity

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Findings from a mouse model of multiple sclerosis suggest that regulatory T cells alone cannot outduel pathogenic T cells in the central nervous system. The observations may have implications for experimental approaches designed to dampen autoimmune diseases by infusion of regulatory T cells (pages 423–431).

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Figure 1: T-reg fail to control CNS T-eff at the peak of EAE.

Kim Caesar

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Authors and Affiliations

  1. Department of Neurology and Program in Immunology, University of California San Francisco, San Francisco, 94143, California, USA

    Thomas Prod'homme, Martin S Weber & Scott S Zamvil

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  1. Thomas Prod'homme
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  2. Martin S Weber
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  3. Scott S Zamvil
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Prod'homme, T., Weber, M. & Zamvil, S. T effectors outfox T regulators in autoimmunity. Nat Med 13, 411–413 (2007). https://doi.org/10.1038/nm0407-411

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