Skip to main content

Advertisement

Log in

The skinny on CD39 in immunity and inflammation

  • News & Views
  • Published:

From Nature Medicine

View current issue Submit your manuscript

The finding that CD39 on Langerhans cells modulates inflammation and immunity in the skin might lead to new strategies to alter immune responses to benefit patients and suggests a new in vitro technique for assessing the irritant potential of topical agents. (pages 358–365)

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: T-cell signaling of dendritic antigen-presenting cells via ATP.

Bob Crimi

References

  1. Langerhans, P. Über die Nerven der menschlichen Haut. Virchows Arch. Pathol. Anat. Physiol. Klin. Med. 44, 325–337 (1868).

    Article  Google Scholar 

  2. Stingl, G. et al. Immunologic functions of Ia-bearing epidermal Langerhans cells. J. Immunol. 121, 2005–2013 (1978).

    CAS  PubMed  Google Scholar 

  3. Silberberg, I., Baer, R.L., Rosenthal, A.S. The role of Langerhans cells in allergic contact hypersensitivity. A review of findings in man and guinea pigs. 1976. J. Invest. Dermatol. 66, 210–217 (1989).

    Article  Google Scholar 

  4. Stingl, G., Katz, S.I., Shevach, E.M., Rosenthal, A.S. & Green, I. Analogous functions of macrophages and Langerhans cells in the initiation in the immune response. J. Invest. Dermatol. 71, 59–64 (1978).

    Article  CAS  Google Scholar 

  5. Grabbe, S. & Granstein, R.D. Mechanisms of ultraviolet radiation carcinogenesis. Chem. Immunol. 58, 291–313 (1994).

    CAS  PubMed  Google Scholar 

  6. Mizumoto, N. et al. CD39 is the dominant Langerhans cell-associated ecto-NTPDase: Modulatory roles in inflammation and immune responsiveness. Nature Med. 8, 358–365 (2002).

    Article  CAS  Google Scholar 

  7. Wolff, K. & Winkelmann, R.K. Ultrastructural localization of nucleoside triphosphatase in Langerhans cells. J. Invest. Dermatol. 48, 50–54 (1967)

    Article  CAS  Google Scholar 

  8. Maliszewski, C.R. et al. the CD39 lymphoid cell activation antigen. Molecular cloning and structural characterization. J. Immunol. 146, 2235–2244 (1991).

    Google Scholar 

  9. Coutinho-Silva, R. et al. P2Z/P2X7 receptor-dependent apoptosis of dendritic cells. Am. J. Physiol. 276, C1139–C1147 (1999).

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Granstein, R. The skinny on CD39 in immunity and inflammation. Nat Med 8, 336–338 (2002). https://doi.org/10.1038/nm0402-336

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0402-336

  • Springer Nature America, Inc.

Navigation