Binding of an endogenous heat shock protein to HLA-DR4 may influence antigen processing pathways and be relevant to rheumatoid arthritis (pages 306–310).
References
Stastny, P. Association of the B-Cell alloantigen DRw4 with rheumatoid arthritis. N. Engl. J. Med. 298, 869–871 (1978).
Auger, I., Escola, J.M., Gorvel, J.P. & Roudier, J. HLA-DR4 and HLA-DR10 motifs that carry susceptibility to rheumatoid arthritis bind 70-kD heat shock proteins. Nature Med. 2, 306–310 (1996).
Oilier, W. & Thomson, W. Population genetics of rheumatoid arthritis. in Rheumatic Disease Clinics of North America (ed. Dudlick, B.) 741–759 (Saunders, Pennsylvania, 1992).
Gregersen, P.K., Silver, J. & Winchester, R.J. The shared epitope hypothesis: An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum. 30, 1205–1213 (1987).
Roudier, J., Petersen, J., Rhodes, G., Luka, J. & Carson, D.A. Susceptibility to rheumatoid arthritis maps to a T Cell epitope shared by the HLA-Dw4 DRβ1 chain and the Epstein Barr virus glycoprotein gp110. Proc. Natl. Acad. Sci. USA 86, 5104–5108 (1989).
MacGregor, A., Oilier, W., Thomson, W., Jawaheer, D. & Silman, A. HLA-DRB1*0401/*0404 genotype and rheumatoid arthritis, increased association in men, young age at onset and disease severity. J. Rheumatol. 22, 1032–1036 (1995).
Salvat, S. et al. Tolerance to a self peptide from the third hypervariable region of HLA-DRB1*0401 in rheumatoid arthritis patients and normal subjects. J. Immunol. 153, 5321–5329 (1994)
Sargent, C.A., Dunham, I., Trowsdale, J. & Campbell, R.D. Human major histocompatibility complex contains genes for the major heat shock protein HSP70. Proc. Natl. Acad. Sci. USA 86, 1968–1972 (1989).
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Ollier, B. Shock revelations about HLA–DR4 — a shortcut to rheumatoid arthritis?. Nat Med 2, 279–280 (1996). https://doi.org/10.1038/nm0396-279
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DOI: https://doi.org/10.1038/nm0396-279
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