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Hugging tight in Huntington's

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An Erratum to this article was published on 07 April 2011

A Corrigendum to this article was published on 07 April 2011

This article has been updated

Mitochondrial fission-fusion and trafficking are altered in the fatal neurodegenerative disorder Huntington's disease. Huntingtin is now shown to function directly in these processes by binding the mitochondrial fission factor dynamin-related protein-1 (DRP1). Mutant huntingtin binds more tightly to DRP1, leading to increased mitochondrial fission and neuronal death, highlighting DRP1 as a potential therapeutic target in Huntington's disease (pages 377–382).

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Figure 1: Mutant huntingtin disrupts the mitochondrial fission-fusion balance, leading to Huntington's disease pathology.

Change history

  • 07 April 2011

     In the version of this article initially published, the first author of the primary paper that the N&V referred to was incorrectly cited as Petrilli. The correct first author is Song. The error has been corrected in the HTML and PDF versions of the article.

  • 07 April 2011

     In the version of this article initially published, the authors omitted to mention that L. Scorrano and colleagues had previously shown increased Drp1 activity and mitochondrial fission in cellular models of Huntington’s disease and would now like to cite this work (EMBO Mol. Med. 2, 490–503, 2010). The error has been corrected in the HTML and PDF versions of the article.

References

  1. Browne, S.E. & Beal, M.F. Neurochem. Res. 29, 531–546 (2004).

    Google Scholar 

  2. McGill, J.K. & Beal, M.F. Cell 127, 465–468 (2006).

    Google Scholar 

  3. Chaturvedi, R.K. et al. Hum. Mol. Genet. 19, 3190–3205 (2010).

    Google Scholar 

  4. Reddy, P.H. et al. Brain Res. Rev. 61, 33–48 (2009).

    Google Scholar 

  5. Li, Z. et al. Cell 119, 873–887 (2004).

    Google Scholar 

  6. Song, W. et al. Nat. Med. 17, 377–382 (2011).

    Google Scholar 

  7. Wang, H. et al. Hum. Mol. Genet. 18, 737–752 (2009).

    Google Scholar 

  8. Kim, J. et al. Hum. Mol. Genet. 19, 3919–3935 (2010).

    Google Scholar 

  9. Shirendeb, U. et al. Hum. Mol. Genet. published online, 10.1093/hmg/ddr024 (21 January 2011).

  10. Cui, L. et al. Cell 127, 59–69 (2006).

    Google Scholar 

  11. Weydt, P. et al. Cell Metab. 4, 349–362 (2006).

    Google Scholar 

  12. Macia, E. et al. Dev. Cell 10, 839–850 (2006).

    Google Scholar 

  13. Cassidy-Stone, A. et al. Dev. Cell 14, 193–204 (2008).

    Google Scholar 

  14. Lackner, L.L. & Nunnari, J. Chem. Biol. 17, 578–583 (2010).

    Google Scholar 

  15. Costa, V. et al. EMBO Mol. Med. 2, 490–503 (2010).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Ashu Johri and M. Flint Beal are at the Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, New York, USA.,

    Ashu Johri & M Flint Beal

  2. Rajnish K. Chaturvedi is in the Developmental Toxicology Division, Indian Institute of Toxicology Research, Lucknow, India.,

    Rajnish K Chaturvedi

Authors
  1. Ashu Johri
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  2. Rajnish K Chaturvedi
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  3. M Flint Beal
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Corresponding author

Correspondence to M Flint Beal.

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The authors declare no competing financial interests.

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Johri, A., Chaturvedi, R. & Beal, M. Hugging tight in Huntington's. Nat Med 17, 245–246 (2011). https://doi.org/10.1038/nm0311-245

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