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Spasticity: a switch from inhibition to excitation

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The involuntary muscle spasms that occur as a result of neuromotor disorders and spinal cord injury can have dangerous consequences for affected individuals. New findings shed light on one mechanism contributing to spasticity: limited chloride transport in motoneurons (pages 302–307).

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Figure 1: Spasticity results from changes in the regulation of intracellular chloride ions in motoneurons.

Katie Vicari

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Authors and Affiliations

  1. V. Reggie Edgerton and Roland R. Roy are in the Department of Physiological Science and Brain Research Institute, Los Angeles, California, USA,

    V Reggie Edgerton & Roland R Roy

  2. V. Reggie Edgerton is also in the Department of Neurobiology, University of California, Los Angeles, Los Angeles, California, USA.,

    V Reggie Edgerton

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  1. V Reggie Edgerton
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  2. Roland R Roy
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Correspondence to V Reggie Edgerton.

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Edgerton, V., Roy, R. Spasticity: a switch from inhibition to excitation. Nat Med 16, 270–271 (2010). https://doi.org/10.1038/nm0310-270

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