Persistence of Mycobacterium tuberculosis in humans depends on its ability to survive within the host macrophage. So the bacterium must resist antimicrobial mechanisms or subvert macrophage signaling pathways to prevent its death. Recent evidence suggests that the two strategies are not mutually exclusive.
This is a preview of subscription content, log in via an institution to check access.
Simon Fenwick
References
Voskuil, M.I. et al. J. Exp. Med. 198, 705–713 (2003).
Walburger, A. et al. Science 304, 1800–1804 (2004).
Rengarajan, J., Bloom, B.R. & Rubin, E.J. Proc. Natl. Acad. Sci. USA 102, 8327–8332 (2005).
Nathan, C. & Shiloh, M.U. Proc. Natl. Acad. Sci. USA 97, 8841–8848 (2000).
Schnappinger, D. et al. J. Exp. Med. 198, 693–704 (2003).
Shi, L., Jung, Y.J., Tyagi, S., Gennaro, M.L. & North, R.J. Proc. Natl. Acad. Sci. USA 100, 241–246 (2003).
Park, H.D. et al. Mol. Microbiol. 48, 833–843 (2003).
Roberts, D.M., Liao, R.P., Wisedchaisri, G., Hol, W.G. & Sherman, D.R. J. Biol. Chem. 279, 23082–23087 (2004).
Leyten, E.M. et al. Microbes Infect. 8, 2052–2060 (2006).
Chua, J., Vergne, I., Master, S. & Deretic, V. Curr. Opin. Microbiol. 7, 71–77 (2004).
Pethe, K. et al. Proc. Natl. Acad. Sci. USA 101, 13642–13647 (2004).
Nguyen, L. et al. J. Bacteriol. 187, 5852–5856 (2005).
Cowley, S. et al. Mol. Microbiol. 52, 1691–1702 (2004).
Niebisch, A., Kabus, A., Schultz, C., Weil, B. & Bott, M. J. Biol. Chem. 281, 12300–12307 (2006).
Sassetti, C.M., Boyd, D.H. & Rubin, E.J. Mol. Microbiol. 48, 77–84 (2003).
Sassetti, C.M. & Rubin, E.J. Proc. Natl. Acad. Sci. USA 100, 12989–12994 (2003).
Hensel, M. et al. Science 269, 400–403 (1995).
Lamichhane, G. & Bishai, W. Nat. Med. 13, 280–282 (2007).
Warner, D.F. & Mizrahi, V. Clin. Microbiol. Rev. 19, 558–570 (2006).
Nguyen, L. & Pieters, J. Trends Cell Biol. 15, 269–276 (2005).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Warner, D., Mizrahi, V. The survival kit of Mycobacterium tuberculosis. Nat Med 13, 282–284 (2007). https://doi.org/10.1038/nm0307-282
Issue Date:
DOI: https://doi.org/10.1038/nm0307-282
- Springer Nature America, Inc.
This article is cited by
-
An investigation of tuberculosis progression revealing the role of macrophages apoptosis via sensitivity and bifurcation analysis
Journal of Mathematical Biology (2021)
-
Understanding the role of interactions between host and Mycobacterium tuberculosis under hypoxic condition: an in silico approach
BMC Genomics (2018)
-
Identification of Potential Antituberculosis Drugs Through Docking and Virtual Screening
Interdisciplinary Sciences: Computational Life Sciences (2018)
-
Macrophage-microbe interaction: lessons learned from the pathogen Mycobacterium tuberculosis
Seminars in Immunopathology (2018)
-
Pharmacokinetic-Pharmacodynamic modelling of intracellular Mycobacterium tuberculosis growth and kill rates is predictive of clinical treatment duration
Scientific Reports (2017)