Heart researchers have had hints that a stress response protein, PKC-α, influences the progression to heart failure. The inner workings of this key regulator are now coming to light (pages 248–254).
References
Houser, S.R. & Margulies, K.B. Circ. Res. 92, 350–358 (2003).
MacLennan, D.H. & Kranias, E.G. Nat. Rev. Mol. Cell Biol. 4, 566–577 (2003).
Braz, J.C. et al. Nat Med 10, 248–254 (2004).
Hahn, H.S. et al. Circ. Res. 93, 1111–1119 (2003).
Bowling, N. et al. Circulation 99, 384–391 (1999).
Wang, J., Liu, X., Sentex, E., Takeda, N. & Dhalla, N.S. Am. J. Physiol. Heart Circ. Physiol. 284, H2277–H2287 (2003).
Vlahos, C.J., McDowell, S.A. & Clerk, A. Nat. Rev. Drug Discov. 2, 99–113 (2003).
Porter, M.J. et al. Am. J. Physiol. Cell. Physiol. 285, C39–C47 (2003).
Cross, H.R., Murphy, E., Bolli, R., Ping, P. & Steenbergen, C. J. Mol. Cell. Cardiol. 34, 361–367 (2002).
Bayer, A.L. et al. Mol. Cell. Biochem. 242, 145–152 (2003).
Wakasaki, H. et al. Proc. Natl. Acad. Sci. USA 94, 9320–9325 (1997).
Chen, L. et al. Proc. Natl. Acad. Sci. USA 98, 11114–11119 (2001).
Takeishi, Y., Jalili, T., Ball, N.A. & Walsh, R.A. Circ. Res. 85, 264–271 (1999).
Takeishi, Y. et al. Cardiovasc. Res. 45, 883–888 (2000).
del Monte, F. & Hajjar, R.J. J. Physiol. 546, 49–61 (2003).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Champion, H., Kass, D. Calcium handler mishandles heart. Nat Med 10, 239–240 (2004). https://doi.org/10.1038/nm0304-239
Issue Date:
DOI: https://doi.org/10.1038/nm0304-239
- Springer Nature America, Inc.
This article is cited by
-
Phospholipase D1 Signaling: Essential Roles in Neural Stem Cell Differentiation
Journal of Molecular Neuroscience (2018)