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AML-1 steps up to the platelets

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Conditional removal of the putative tumor suppressor gene Aml1/Runx1 from the bone marrow of mice mimics a human familial platelet disorder (pages 299–304).

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Figure 1: AML-1 (encoded by Runx1) in hematopoiesis and leukemogenesis.

Renee Lucas

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Irvin, B., Hiebert, S. AML-1 steps up to the platelets. Nat Med 10, 238–239 (2004). https://doi.org/10.1038/nm0304-238

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