Chronic inflammation is associated with obesity, but the pathways that mediate this phenomenon are not fully characterized. The nucleotide-binding domain, leucine-rich–containing family, pyrin domain–containing-3 (Nlrp3) inflammasome functions as a sensor to detect danger signals and induce downstream inflammatory signaling that contributes to obesity-associated conditions such as insulin resistance (pages 179–188).
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Horng, T., Hotamisligil, G. Linking the inflammasome to obesity-related disease. Nat Med 17, 164–165 (2011). https://doi.org/10.1038/nm0211-164
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DOI: https://doi.org/10.1038/nm0211-164
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