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Stemming a tumor with a little miR

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A microRNA decreases the expression of the adhesion molecule CD44 in prostate cancer stem cells (CSCs), blocking tumor growth and metastasis in mice (pages 211–215). Systemic delivery of this negative regulator may open new avenues for targeting CSCs to halt cancer.

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Figure 1: miR34a inhibits prostate CSCs, which drive the growth and metastatic potential of prostate cancers.

Marina Corral

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Authors and Affiliations

  1. Max S. Wicha is at the University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, USA.,

    Max S Wicha

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  1. Max S Wicha
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Correspondence to Max S Wicha.

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Competing interests

M.S.W. is a scientific advisor and holds equity in Oncomed Pharmaceuticals.

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Wicha, M. Stemming a tumor with a little miR. Nat Med 17, 162–164 (2011). https://doi.org/10.1038/nm0211-162

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