Skip to main content

Advertisement

SpringerLink
Log in

Inflammatory proteinase slips into tumor cells

  • News & Views
  • Published:

From Nature Medicine

View current issue Submit your manuscript

Inflammatory cells can promote tumor cell proliferation, but the range of mechanisms has not been fully explored. A proteinase produced by neutrophils is now shown to enter tumor cells and promote their proliferation (pages 219–223).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Neutrophil elastase controls tumor cell proliferation.

Katie Vicari

References

  1. Edwards, B.K. et al. Cancer published online, doi:10.1002/cncr.24760 (7 December 2009).

  2. Houghton, A.M., et al. Nat. Med. 16, 219–223 (2010).

    Google Scholar 

  3. Lewis, C.E. & Pollard, J.W. Cancer Res. 66, 605–612 (2006).

    Google Scholar 

  4. Fridlender, Z.G. et al. Cancer Cell 16, 183–194 (2009).

    Google Scholar 

  5. Lungarella, G., Cavarra, E., Lucattelli, M. & Martorana, P.A. Int. J. Biochem. Cell Biol. 40, 1287–1296 (2008).

    Google Scholar 

  6. Kawahara, Y., et al. Dis. Esophagus published online, doi:10.1111/j.1442-2050.2009.01010.x (25 September 2009).

  7. Schulz, R. Annu. Rev. Pharmacol. Toxicol. 47, 211–242 (2007).

    Google Scholar 

  8. Boivin, W.A., Cooper, D.M., Hiebert, P.R. & Granville, D.J. Lab. Invest. 89, 1195–1220 (2009).

    Google Scholar 

  9. Johnston, N., Wells, C.W., Blumin, J.H., Toohill, R.J. & Merati, A.L. Ann. Otol. Rhinol. Laryngol. 116, 934–938 (2007).

    Google Scholar 

  10. Wymann, M.P. & Schneiter, R. Nat. Rev. Mol. Cell Biol. 9, 162–176 (2008).

    Google Scholar 

  11. Koshiol, J. et al. PLoS One 4, e7380 (2009).

    Google Scholar 

  12. Stathopoulos, G.T. et al. Mol. Cancer Res. 6, 364–371 (2008).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Barbara Fingleton is in the Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.,

    Barbara Fingleton

Authors
  1. Barbara Fingleton
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Barbara Fingleton.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fingleton, B. Inflammatory proteinase slips into tumor cells. Nat Med 16, 161–163 (2010). https://doi.org/10.1038/nm0210-161

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0210-161

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation