Skip to main content

Advertisement

SpringerLink
Log in

Orexins: looking forward to sleep, back at addiction

  • News & Views
  • Published:

From Nature Medicine

View current issue Submit your manuscript

An orally available drug enters the brain and interferes with signaling of orexin neuropeptides—providing a potential treatment for sleep disorders and possibly addiction (pages 150–155).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Among their many functions, the orexin neurons promote wakefulness and modulate reward pathways.

Katie Ris

References

  1. Siegel, J.M. Annu. Rev. Psychol. 55, 125148 (2004).

    Article  Google Scholar 

  2. Brisbare-Roch, C. et al. Nat. Med. 13, 150–155 (2007).

    Article  CAS  Google Scholar 

  3. Peyron, C. et al. Nat. Med. 6, 991–997 (2000).

    Article  CAS  Google Scholar 

  4. Thannickal, T.C. et al. Neuron 27, 469–474 (2000).

    Article  CAS  Google Scholar 

  5. Crocker, A. et al. Neurology 65, 1184–1188 (2005).

    Article  CAS  Google Scholar 

  6. Lee, M.G., Hassani, O.K. & Jones, B.E. J. Neurosci. 25, 6716–6720 (2005).

    Article  CAS  Google Scholar 

  7. Mileykovskiy, B.Y., Kiyashchenko, L.I. & Siegel, J.M. Neuron 46, 787–798 (2005).

    Article  CAS  Google Scholar 

  8. Estabrooke, I.V. et al. J. Neurosci. 21, 1656–1662 (2001).

    Article  CAS  Google Scholar 

  9. Chemelli, R.M. et al. Cell 98, 437–451 (1999).

    Article  CAS  Google Scholar 

  10. Beuckmann, C.T. et al. J. Neurosci. 24, 4469–4477 (2004).

    Article  CAS  Google Scholar 

  11. Lin, L. et al. Cell 98, 365–376 (1999).

    Article  CAS  Google Scholar 

  12. Mochizuki, T. et al. J. Neurosci. 24, 6291–6300 (2004).

    Article  CAS  Google Scholar 

  13. Harris, G.C., Wimmer, M. & Aston-Jones, G. Nature 437, 556–559 (2005).

    Article  CAS  Google Scholar 

  14. Hara, J., Yanagisawa, M. & Sakurai, T. Neurosci. Lett. 380, 239–242 (2005).

    Article  CAS  Google Scholar 

  15. Narita, M. et al. J. Neurosci. 26, 398–405 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurology, Beth Israel Deaconess Medical Center, 77 Avenue Louis Pasteur, Boston, 02115, Massachusetts, USA

    Thomas E Scammell & Clifford B Saper

Authors
  1. Thomas E Scammell
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Clifford B Saper
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Scammell, T., Saper, C. Orexins: looking forward to sleep, back at addiction. Nat Med 13, 126–128 (2007). https://doi.org/10.1038/nm0207-126

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0207-126

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation