A new study identifies the chemokine CCL27 and its receptor CCR10 as important homing molecules for T-cell migration to the skin. Moreover, they find that CCL27 inhibition suppresses some skin-inflammatory responses, suggesting that therapies targeting CCL10 could be used to treat several human skin disorders. (pages 157–165)
References
Homey, B. et al. CCL27/CCR10 interactions regulate T cell-mediated skin inflammation. Nature Med. 7, 157–165 (2002).
Butcher, E.C. & Picker, L.J. Lymphocyte homing and homeostasis. Science 272, 60–66 (1996).
von Andrian, U.H. & Mackay, C.R. T cell function and migration. Two sides of the same coin. N. Eng. J. Med. 343, 1020–1034 (2000).
Morales, J. et al. CTACK, a skin-associated chemokine that preferentially attracts skin- homing memory T cells. Proc. Natl. Acad. Sci. USA 96, 14470–14475 (1999).
Campbell, D.J. & Butcher, E.C. Rapid acquisition of tissue-specific homing phenotypes by CD4+ T cells activated in cutaneous or mucosal lymphoid tissues. J. Exp. Med. 195, 135–141 (2002).
Campbell, J.J. et al. The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells. Nature 400, 776–780 (1999).
Reiss, Y., Proudfoot, A.E., Power, C.A., Campbell, J.J. & Butcher, E.C. CC chemokine receptor (CCR)4 and the CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to inflamed skin. J. Exp. Med. 194, 1541–1547 (2001).
Butcher, E.C. Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell 67, 1033–1036 (1991).
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Mackay, C. New avenues for anti-inflammatory therapy. Nat Med 8, 117–118 (2002). https://doi.org/10.1038/nm0202-117
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DOI: https://doi.org/10.1038/nm0202-117
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