Skip to main content

Advertisement

SpringerLink
Log in

Filtering new facts about kidney disease

  • News & Views
  • Published:

From Nature Medicine

View current issue Submit your manuscript

Loss of kidney filter function during nephrotic syndrome results in loss of protein from the blood into the urine (proteinuria). A new study mechanistically links proteinuria to dysregulated expression and post-transcriptional modification of the secreted glycoprotein angiopoietin-like-4 in kidney glomerular podocytes (pages 117–122).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Schematic outlining the development of reversible MCD in contrast to alternative pathways that cause progressive podocyte disease, such as focal segmental glomerulosclerosis (FSGS).

Katie Vicari

References

  1. Muller, F. Verhand. der Deutsch. Path. Gesellschaft 64–69 (1905).

    Google Scholar 

  2. du Bray, E.S. Metabolism 1, 47–48 (1928).

    Google Scholar 

  3. Clement, L.C. et al. Nat. Med. 17, 117–122 (2011).

    Article  CAS  Google Scholar 

  4. Hato, T. et al. Trends Cardiovasc. Med. 18, 6–14 (2008).

    Article  CAS  Google Scholar 

  5. Romeo, S. et al. J. Clin. Invest. 119, 70–79 (2009).

    CAS  PubMed  Google Scholar 

  6. Liu, G. et al. J. Biol. Chem. 281, 39681–39692 (2006).

    Article  CAS  Google Scholar 

  7. Galeano, B. et al. J. Clin. Invest. 117, 1585–1594 (2007).

    Article  CAS  Google Scholar 

  8. Reiser, J. et al. J. Clin. Invest. 113, 1390–1397 (2004).

    Article  CAS  Google Scholar 

  9. Zhang, S.Y. et al. Sci. Signal. 3, ra39 (2010).

    PubMed  PubMed Central  Google Scholar 

  10. Reiser, J. et al. J. Clin. Invest. 120, 3421–3431 (2010).

    Article  CAS  Google Scholar 

  11. Wei, C. et al. Nat. Med. 14, 55–63 (2008).

    Article  CAS  Google Scholar 

  12. Niranjan, T. et al. Nat. Med. 14, 290–298 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Jochen Reiser is in the Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA,

    Jochen Reiser

Authors
  1. Jochen Reiser
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jochen Reiser.

Ethics declarations

Competing interests

J.R. is an inventor on issued and pending patents related to the discoveries of β3 integrin function and cathepsin L in podocytes and glomerular diseases. He stands to gain royalties from future commercialization.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Reiser, J. Filtering new facts about kidney disease. Nat Med 17, 44–45 (2011). https://doi.org/10.1038/nm0111-44

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0111-44

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation