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Adenosine receptor crossroads in sickle cell disease

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Adenosine therapy for sickle cell disease has been proposed to improve blood flow, mediate cytoprotection and inhibit natural killer cell activity. Complicating this approach, adenosine signaling also induces hemoglobin S polymerization, promoting 'sickling', vasoocclusion, hemolysis and organ damage (pages 79–86).

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Figure 1: Adenosine worsens SCD by increasing 2,3-DPG in red blood cells through the A2B receptor.

Katie Vicari

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Acknowledgements

I thank S. Tofovic and E. Jackson, University of Pittsburgh, for helpful comments and insights on adenosine biology.

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Authors and Affiliations

  1. Mark T. Gladwin is chief of the Division of Pulmonary, Allergy and Critical Care Medicine and director of the Vascular Medicine Institute, University of Pittsburgh, Pennsylvania, USA,

    Mark T Gladwin

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  1. Mark T Gladwin
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Correspondence to Mark T Gladwin.

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Gladwin, M. Adenosine receptor crossroads in sickle cell disease. Nat Med 17, 38–40 (2011). https://doi.org/10.1038/nm0111-38

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