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Vasopressin: friend or foe?

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Vasopressin plays a vital part in homeostasis by regulating water excretion in the kidney. But it seems that vasopressin also dampens the inflammatory response to uropathogenic Escherichia coli—a finding that adds to a growing list of adverse actions of the 'antidiuretic hormone'.

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Figure 1: Role of vasopressin in the physiological regulation of systemic water balance (yellow boxes) and the regulation of the state of proinflammatory activation of collecting-duct cells (blue boxes).

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Authors and Affiliations

  1. Mark A. Knepper is in the Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung and Blood Institute, US National Institutes of Health, Bethesda, Maryland 20892, USA. knep@helix.nih.gov,

    Mark A Knepper

  2. Robert A. Star is in the Renal Diagnostics and Therapeutics Unit, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health. Bethesda, Maryland 20892, USA.,

    Robert A Star

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  1. Mark A Knepper
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  2. Robert A Star
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Knepper, M., Star, R. Vasopressin: friend or foe?. Nat Med 14, 14–16 (2008). https://doi.org/10.1038/nm0108-14

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