Defects in organelle biogenesis and trafficking underlie a newly described genetic disorder. These defects are traced to the gene encoding a scaffolding protein that coordinates signal transduction events on late endosomes (pages 38–45).
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Katie Ris
References
Bohn, G. et al. Nat. Med. 13, 36–43 (2006).
Wunderlich, W. et al. J. Cell Biol. 152, 765–776 (2001).
Stinchcombe, J., Bossi, G. & Griffiths, G.M. Science 305, 55–59 (2004).
Gunay-Aygun, M. et al. Semin. Thromb. Hemost. 30, 537–547 (2004).
Ménasché, G. et al. J. Clin. Invest. 112, 450–456 (2003).
Schiaffino, M.V. et al. Nat. Genet. 23, 108–112 (1999).
Kurzbauer, R. et al. Proc. Natl. Acad. Sci. USA 101, 10984–10989 (2004).
Lunin, V.V. et al. J. Biol. Chem. 279, 23422–23430 (2004).
Teis, D., Wunderlich, W. & Huber, L.A. Dev. Cell 3, 803–814 (2002).
Nazarian, R., Falcón-Pérez, J.M. & Dell'Angelica, E.C. Proc. Natl. Acad. Sci. USA 100, 8770–8775 (2003).
Deacon, S.W., Nascimento, A., Serpinskaya, A.S. & Gelfand, V.I. Curr. Biol. 15, 459–463 (2005).
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Dell'Angelica, E. Bad signals jam organelle traffic. Nat Med 13, 31–32 (2007). https://doi.org/10.1038/nm0107-31
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DOI: https://doi.org/10.1038/nm0107-31
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