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When the Clock stops ticking, metabolic syndrome explodes

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Circadian control depends on oscillating transcription factors, master switches synchronized by stimuli such as light and feeding. Recent studies show that altering circadian rhythmicity also results in pathophysiological changes resembling the metabolic syndrome.

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Figure 1: Transcriptional control of metabolic pathways by circadian oscillators.

Simon Fenwick

Figure 2: Interplay between transcription factors of the Clock machinery and the nuclear receptor superfamily in metabolic control.

Simon Fenwick

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Authors and Affiliations

  1. Département d'Athérosclérose, Institut Pasteur de Lille, Lille, F-59019, France

    Bart Staels

  2. Inserm, U545, Lille, F-59019, France

    Bart Staels

  3. Université de Lille 2, Lille, F-59006, France

    Bart Staels

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  1. Bart Staels
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Staels, B. When the Clock stops ticking, metabolic syndrome explodes. Nat Med 12, 54–55 (2006). https://doi.org/10.1038/nm0106-54

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