A reduction in mitochondrial activity and the subsequent decrease in energy expenditure contribute substantially to metabolic dysfunction in aging, insulin resistance and diabetes. Enhancing mitochondrial activity could improve metabolic homeostasis.
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Simon Fenwick
References
Petersen, K.F. et al. Science 300, 1140–1142 (2003).
Petersen, K.F., Dufour, S., Befroy, D., Garcia, R. & Shulman, G.I. N. Engl. J. Med. 350, 664–671 (2004).
Wisloff, U. et al. Science 307, 418–420 (2005).
Mootha, V.K. et al. Nat. Genet. 34, 267–273 (2003).
Patti, M.E. et al. Proc. Natl. Acad. Sci. USA 100, 8466–8471 (2003).
Puigserver, P. et al. Cell 92, 829–839 (1998).
Lin, J. et al. Cell 119, 121–135 (2004).
Picard, F. et al. Cell 111, 931–941 (2002).
Leonardsson, G. et al. Proc. Natl. Acad. Sci. USA 101, 8437–8442 (2004).
Rodgers, J.T. et al. Nature 434, 113–118 (2005).
Tanaka, T. et al. Proc. Natl. Acad. Sci. USA 100, 15924–15929 (2003).
Mootha, V.K. et al. Proc. Natl. Acad. Sci. USA 101, 6570–6575 (2004).
Wang, Y.X. et al. PLoS Biol 2, e294 (2004).
Houten, S.M. & Auwerx, J. Cell 119, 5–7 (2004).
Um, S.H. et al. Nature 431, 200–205 (2004).
Rocchi, S. et al. Mol. Cell 8, 737–747 (2001).
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Auwerx, J. Improving metabolism by increasing energy expenditure. Nat Med 12, 44–45 (2006). https://doi.org/10.1038/nm0106-44
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DOI: https://doi.org/10.1038/nm0106-44
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