Defects in the ability of fat cells to transport glucose are linked to insulin resistance in muscle and liver. Retinol binding protein 4 (RBP4) now comes to the fore as a new adipokine, linking glucose uptake in adipocytes with systemic insulin sensitivity.
This is a preview of subscription content, log in via an institution to check access.
Simon Fenwick
References
Shepherd, P.R. & Kahn, B.B. N. Engl. J. Med. 341, 248–257 (1999).
Shepherd, P.R. et al. J. Biol. Chem. 268, 22243–22246 (1993).
Abel, E.D. et al. Nature 409, 729–733 (2001).
Zisman, A. et al. Nat. Med. 6, 924–928 (2000).
Yang, Q. et al. Nature 436, 356–362 (2005).
Blüher, M. et al. Dev. Cell 3, 25–38 (2002).
Farnier, C. et al. Int. J. Obes. Relat. Metab. Disord. 27, 1178–1186 (2003).
Furukawa, S. et al. J. Clin. Invest. 14, 1752–1761 (2004).
Kershaw, E.E. & Flier, J.S. J. Clin. Endocrinol. Metab. 89, 2548–2556 (2004)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tamori, Y., Sakaue, H. & Kasuga, M. RBP4, an unexpected adipokine. Nat Med 12, 30–31 (2006). https://doi.org/10.1038/nm0106-30
Issue Date:
DOI: https://doi.org/10.1038/nm0106-30
- Springer Nature America, Inc.
This article is cited by
-
The impact of reactive oxygen species in the development of cardiometabolic disorders: a review
Lipids in Health and Disease (2021)
-
Serum level and polymorphisms of retinol-binding protein-4 and risk for gestational diabetes mellitus: a meta-analysis
BMC Pregnancy and Childbirth (2016)
-
Relationship of serum retinol-binding protein 4 with weight status and lipid profile among Korean children and adults
European Journal of Clinical Nutrition (2011)
-
Variations of retinol binding protein 4 levels are not associated with changes in insulin resistance during puberty
Journal of Endocrinological Investigation (2009)
-
Differential screening identifies transcripts with depot-dependent expression in white adipose tissues
BMC Genomics (2008)