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Androgen receptor outwits prostate cancer drugs

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Almost all prostate cancer patients become resistant to therapy that blocks androgen-mediated cell proliferation. The key to this resistance may lie in expression of the androgen receptor itself (pages 33–39).

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Figure 1: Androgen receptor signaling in normal and malignant prostate cells.

Ann Thomson

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Authors and Affiliations

  1. The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, Baltimore, 21287, Maryland, USA

    John T Isaacs

  2. Department of Urology, Johns Hopkins University, School of Medicine, Baltimore, 21287, Maryland, USA

    William B Isaacs

Authors
  1. John T Isaacs
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  2. William B Isaacs
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Isaacs, J., Isaacs, W. Androgen receptor outwits prostate cancer drugs. Nat Med 10, 26–27 (2004). https://doi.org/10.1038/nm0104-26

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