Tumor-specific, 'signature' mutations of p53 have been identified in several cancers. The molecular basis of these tissue-specific selections has been poorly understood. A recent report sheds light on this issue by identifying the molecular basis of one such signature mutation found in adrenal cortical carcinomas.
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References
Hainaut, P. & Hollstein, M. The p53 tumor suppressor gene: The first ten thousand mutations. Adv. Cancer Res . 77, 81–137 (2000).
Malkin, D. et al. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 250, 1233–1238 (1990).
DiGiammarino, E.L. et al. A novel mechanism of tumorigenesis involving pH-dependent destabilization of a mutant p53 tetramer. Nature Struct. Biol. 9, 12–16 (2002).
Ribeiro, R.C. et al. An inherited p53 mutation that contributes in a tissue-specific manner to pediatric adrenal cortical carcinoma. Proc. Natl. Acad. Sci. USA 98, 9330–9335 (2001).
Lomax, M.E., Barnes, D.M., Hupp, T.R., Picksley, S.M. & Camplejohn, R.S. Characterization of p53 oligomerization domain mutations isolated from Li–Fraumeni and Li–Fraumeni like family members. Oncogene 17, 643–649 (1998).
Jeffrey, P.D., Gorina, S. & Pavletich, N.P. Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms. Science 267, 1498–1502 (1995).
Spencer, S.J., Mesiano, S., Lee, J.Y. & Jaffe, R.B. Proliferation and apoptosis in the human adrenal cortex during the fetal and perinatal periods: implications for growth and remodeling. J. Clin. Endocrinol. Metab. 84, 1110–1115 (1999).
Birch, J.M. et al. Relative frequency and morphology of cancers in carriers of germline TP53 mutations. Oncogene 20, 4621–4628 (2001).
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Hainaut, P. Tumor-specific mutations in p53: The acid test. Nat Med 8, 21–23 (2002). https://doi.org/10.1038/nm0102-21
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DOI: https://doi.org/10.1038/nm0102-21
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