The presence of multiple inflammatory cytokines predicts the failure of a topical 1% tenofovir microbicide gel to protect women against HIV infection.
References
Notario-Pérez, F., Ruiz-Caro, R. & Veiga-Ochoa, M.D. Drug Des. Devel. Ther. 11, 1767–1787 (2017).
Hope, T.J. & Marrazzo, J.M. AIDS Res. Hum. Retroviruses 31, 1055–1059 (2015).
Molina, J.M. et al. Lancet HIV 4, e402–e410 (2017).
Abdool Karim, Q. et al. Science 329, 1168–1174 (2010).
Baeten, J.M. et al. N. Engl. J. Med. 375, 2121–2132 (2016).
Nel, A. et al. N. Engl. J. Med. 375, 2133–2143 (2016).
Klatt, N.R. et al. Science 356, 938–945 (2017).
McKinnon, L.R. et al. Nat. Med. 24, 491–496 (2018).
Haynes, B.F. et al. N. Engl. J. Med. 366, 1275–1286 (2012).
Masson, L. et al. Clin. Infect. Dis. 61, 260–269 (2015).
Cottrell, M.L. et al. J. Infect. Dis. 214, 55–64 (2016).
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Hope, T. Inflammation weakens HIV prevention. Nat Med 24, 384–385 (2018). https://doi.org/10.1038/nm.4534
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DOI: https://doi.org/10.1038/nm.4534
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