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Macrophages and platelets join forces to release kidney-damaging DNA traps

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A recent study in mice dissects the mechanisms through which muscle damage leads to kidney dysfunction and identifies macrophage extracellular trap (MET) formation as a new pathogenic driver and potential therapeutic target.

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Figure 1: Skeletal muscle necrosis leads to kidney failure via MET formation.

Marina Corral Spence/Springer Nature

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Authors and Affiliations

  1. Children's Hospital, University of Tübingen, Tübingen, Germany and Roche Pharma Research & Early Development (pRED), Immunology, Inflammation and Infectious Diseases (I3) Discovery and Translational Area, Roche Innovation Center, Basel, Switzerland

    Dominik Hartl

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  1. Dominik Hartl
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Correspondence to Dominik Hartl.

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Competing interests

D.H. works for a pharmaceutical company (Roche, Research and Early Development).

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Hartl, D. Macrophages and platelets join forces to release kidney-damaging DNA traps. Nat Med 24, 128–129 (2018). https://doi.org/10.1038/nm.4486

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