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Lipid metabolic reprogramming in hepatic ischemia–reperfusion injury

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In a recent study of hepatic ischemia–reperfusion injury (IRI), Zhang et al. use tandem 'omics' approaches in mice, pigs, and nonhuman primates to identify lipid metabolic reprogramming as a key determinant of IRI, thus providing novel mechanistic and therapeutic insights.

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Figure 1: Identification of a novel therapeutic target, ALOX12, in hepatic IRI.

Marina Corral Spence/Springer Nature

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Authors and Affiliations

  1. Division of Experimental Pathology, Department of Pathology,

    Satdarshan P Monga

  2. the Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Pittsburgh, Pennsylvania, USA

    Satdarshan P Monga

  3. the Pittsburgh Liver Research Center, University of Pittsburgh Medical Center and University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Satdarshan P Monga

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  1. Satdarshan P Monga
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Correspondence to Satdarshan P Monga.

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Monga, S. Lipid metabolic reprogramming in hepatic ischemia–reperfusion injury. Nat Med 24, 6–7 (2018). https://doi.org/10.1038/nm.4468

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