Skip to main content
SpringerLink
Log in

Fattening the role of Ca2+ cycling in adaptive thermogenesis

  • News & Views
  • Published:

From Nature Medicine

View current issue Submit your manuscript

A new study shows that deleting uncoupling protein 1 activates Ca2+ cycling thermogenesis within beige fat, protecting mice against cold-induced hypothermia and dysglycemia following diet-induced obesity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Ca2+ cycling thermogenesis is used by beige fat and skeletal muscle to regulate core body temperature, body mass and metabolism.

Katie Vicari/Springer Nature

References

  1. Wu, J. et al. Cell 150, 366–376 (2012).

    Article  CAS  Google Scholar 

  2. Seale, P. et al. J. Clin. Invest. 121, 96–105 (2011).

    Article  CAS  Google Scholar 

  3. Bertholet, A.M. et al. Cell Metab. 25, 811–822 (2017).

    Article  CAS  Google Scholar 

  4. Ikeda, K. et al. Nat. Med. 23, 1454–1465 (2017).

    Article  CAS  Google Scholar 

  5. Smith, I.C., Bombardier, E., Vigna, C. & Tupling, A.R. PLoS One 8, e68924 (2013).

    Article  CAS  Google Scholar 

  6. Bal, N.C. et al. Nat. Med. 18, 1575–1579 (2012).

    Article  CAS  Google Scholar 

  7. Bombardier, E. et al. FASEB J. 587, 1687–1692 (2013).

    Article  CAS  Google Scholar 

  8. Feldmann, H.M., Golozoubova, V., Cannon, B. & Nedergaard, J. Cell Metab. 9, 203–209 (2009).

    Article  CAS  Google Scholar 

  9. Chen, K.Y. et al. Cell Metab. 24, 210–222 (2016).

    Article  CAS  Google Scholar 

  10. Leitner, B.P. et al. Proc. Natl. Acad. Sci. USA 114, 8649–8654 (2017).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. the Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada

    Daniel Gamu & A Russell Tupling

Authors
  1. Daniel Gamu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A Russell Tupling
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A Russell Tupling.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gamu, D., Tupling, A. Fattening the role of Ca2+ cycling in adaptive thermogenesis. Nat Med 23, 1403–1404 (2017). https://doi.org/10.1038/nm.4457

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm.4457

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation