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Reply to The small molecule CLP257 does not modify activity of the K+–Cl− co-transporter KCC2 but does potentiate GABAA receptor activity

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Figure 1: CLP257 enhances KCC2 without affecting GABAA conductance.

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Acknowledgements

We thank J. Asselin and D. Boudreau for characterization of the emission spectrum of CLP257. This work was supported by the Canadian Institutes for Health Research (CIHR), a Consejo Nacional de Ciencia y Tecnología (CONACYT) scholarship to J.P.-S., and Canada Research Chairs to Y.D.K. and R.P.B.

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Authors and Affiliations

  1. CERVO Brain Research Centre, Quebec Mental Health Institute, Quebec, Quebec, Canada

    Martin Gagnon, Marc J Bergeron, Jimena Perez-Sanchez, Isabel Plasencia-Fernández, Louis-Etienne Lorenzo, Antoine G Godin, Annie Castonguay, Robert P Bonin & Yves De Koninck

  2. Exactis Innovation, Montreal, Quebec, Canada

    Martin Gagnon

  3. Department of Psychiatry and Neuroscience, Université Laval, Quebec, Quebec, Canada

    Marc J Bergeron & Yves De Koninck

  4. Graduate Program in Neurobiology, Université Laval, Quebec, Quebec, Canada

    Jimena Perez-Sanchez, Isabel Plasencia-Fernández & Yves De Koninck

  5. Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada

    Robert P Bonin

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  1. Martin Gagnon
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  2. Marc J Bergeron
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  3. Jimena Perez-Sanchez
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  4. Isabel Plasencia-Fernández
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  5. Louis-Etienne Lorenzo
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  6. Antoine G Godin
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  7. Annie Castonguay
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  8. Robert P Bonin
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  9. Yves De Koninck
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Contributions

M.G., A.C., R.P.B., and Y.D.K. conceived the experiments, M.J.B., J.P.-S., I.P.-F., L.-E.L., and A.G.G. performed the experiments, and M.J.B., J.P.-S., I.P.-F., A.G.G., and L.-E.L. analyzed data. A.G.G. and L.-E.L. conceived some of the quantification approaches. All authors contributed to the writing of this manuscript.

Corresponding author

Correspondence to Yves De Koninck.

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The authors declare no competing financial interests.

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Gagnon, M., Bergeron, M., Perez-Sanchez, J. et al. Reply to The small molecule CLP257 does not modify activity of the K+–Cl− co-transporter KCC2 but does potentiate GABAA receptor activity. Nat Med 23, 1396–1398 (2017). https://doi.org/10.1038/nm.4449

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