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Long-range hypoxia signaling in NAFLD

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A recent study describes a role for hypoxic signaling in the small intestine in the etiology of nonalcoholic fatty liver disease (NAFLD) and suggests that HIF-2α inhibitors may be an effective option for the treatment of this disease.

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Figure 1: Intestinal HIF-2α promotes NAFLD.

Katie Vicari/Springer Nature

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Authors and Affiliations

  1. the Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University, Stanford, California, USA

    Edward L LaGory & Amato J Giaccia

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  1. Edward L LaGory
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  2. Amato J Giaccia
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Correspondence to Amato J Giaccia.

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LaGory, E., Giaccia, A. Long-range hypoxia signaling in NAFLD. Nat Med 23, 1251–1252 (2017). https://doi.org/10.1038/nm.4436

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