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An epitranscriptomic vulnerability in myeloid malignancies

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A recent study finds that the N6-methyladenosine (m6A) modifier METTL3 regulates proliferation and differentiation in myeloid cells and acute myeloid leukemia (AML).

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Figure 1: Loss of METTL3 has a context-dependent effect on tumorigenesis.

Katie Vicari/Springer Nature

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Correspondence to Pedro J Batista.

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Schmiechen, A., Batista, P. An epitranscriptomic vulnerability in myeloid malignancies. Nat Med 23, 1252–1254 (2017). https://doi.org/10.1038/nm.4435

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