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Calculated risk: a new single-nucleotide polymorphism linked to severe influenza disease

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Clear links between human genes and susceptibility to influenza disease are scarce. A recent study uncovers a gene variant coupled to severe influenza, and shows how it hampers the expression of an antiviral gene that is key to immune cell survival.

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Figure 1: The rs34481144 allele regulates IFITM3 expression and influenza severity.

Debbie Maizels/Springer Nature

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Acknowledgements

This study was funded by the Leading Advanced Projects for medical innovation (LEAP) from the Japan Agency for Medical Research and Development (AMED); and grant U19AI106772 (to Y.K.), provided by the National Institute of Allergy and Infectious Diseases, US National Institutes of Health. The authors thank S. Watson for editing the manuscript.

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Authors and Affiliations

  1. Department of Pathobiological Sciences, University of Wisconsin–Madison, Madison, Wisconsin, USA

    Amie J Eisfeld & Yoshihiro Kawaoka

  2. Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan

    Yoshihiro Kawaoka

  3. International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan

    Yoshihiro Kawaoka

Authors
  1. Amie J Eisfeld
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  2. Yoshihiro Kawaoka
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Correspondence to Yoshihiro Kawaoka.

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The authors declare no competing financial interests.

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Eisfeld, A., Kawaoka, Y. Calculated risk: a new single-nucleotide polymorphism linked to severe influenza disease. Nat Med 23, 911–912 (2017). https://doi.org/10.1038/nm.4383

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