A new study in mice shows that activation of the brain's reward system boosts beneficial antibacterial immunity in the periphery. These findings provide biological insights into the association between psychological and physical well-being.
This is a preview of subscription content, log in via an institution to check access.
Marina Corral Spence/Nature Publishing Group
References
Glaser, R. & Kiecolt-Glaser, J.K. Nat. Rev. Immunol. 5, 243–251 (2005).
Dantzer, R., O'Connor, J.C., Freund, G.G., Johnson, R.W. & Kelley, K.W. Nat. Rev. Neurosci. 9, 46–56 (2008).
Eisenberger, N.I. & Cole, S.W. Nat. Neurosci. 15, 669–674 (2012).
Segerstrom, S.C. & Miller, G.E. Psychol. Bull. 130, 601–630 (2004).
Schwartz, M., Kipnis, J., Rivest, S. & Prat, A. J. Neurosci. 33, 17587–17596 (2013).
Derecki, N.C. et al. J. Exp. Med. 207, 1067–1080 (2010).
Ben-Shaanan, T.L. et al. Nat. Med. 22, 940–944 (2016).
Armbruster, B.N., Li, X., Pausch, M.H., Herlitze, S. & Roth, B.L. Proc. Natl. Acad. Sci. USA 104, 5163–5168 (2007).
Elenkov, I.J., Wilder, R.L., Chrousos, G.P. & Vizi, E.S. Pharmacol. Rev. 52, 595–638 (2000).
Tracey, K.J. Nat. Rev. Immunol. 9, 418–428 (2009).
Borovikova, L.V. et al. Nature 405, 458–462 (2000).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Frost, E., Lukens, J. The brain's reward circuitry regulates immunity. Nat Med 22, 835–837 (2016). https://doi.org/10.1038/nm.4157
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm.4157
- Springer Nature America, Inc.