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Follicular T helper cells: hotspots for HIV-1 persistence

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Reservoirs of virally infected cells that are resistant to standard antiretroviral therapy make HIV-1 infection an incurable disease. A new study shows that follicular T helper cells in lymph node germinal centers are prime niches for HIV-1 persistence during antiviral therapy.

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Figure 1: Lymph node CXCR5+PD-1+ follicular T helper (TFH) cells are sites of HIV-1 persistence during antiretroviral therapy.

Marina Corral Spence/Nature Publishing Group

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Acknowledgements

M.P. is supported by NIH grants AI110334 and AI104278. M.L. is supported by NIH grants AI106468, AI114235, AI117841, AI120008 and AI098487.

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Authors and Affiliations

  1. Mirko Paiardini is at the Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA and at the Yerkes National Primate Research Center, Atlanta, Georgia, USA.,

    Mirko Paiardini

  2. Mathias Lichterfeld is at the Infectious Disease Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA and at the Ragon Institute of Massachusetts General Hospital, MIT and Harvard University, Cambridge, Massachusetts, USA.,

    Mathias Lichterfeld

Authors
  1. Mirko Paiardini
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  2. Mathias Lichterfeld
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Correspondence to Mathias Lichterfeld.

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The authors declare no competing financial interests.

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Paiardini, M., Lichterfeld, M. Follicular T helper cells: hotspots for HIV-1 persistence. Nat Med 22, 711–712 (2016). https://doi.org/10.1038/nm.4138

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