A recent study shows that skeletal muscle responds to tumor-secreted factors by undergoing a change in fatty acid metabolism, and that blocking this metabolic response in mice inhibits muscle wasting.
This is a preview of subscription content, log in via an institution to check access.
References
Fearon, K.C., Glass, D.J. & Guttridge, D.C. Cell Metab. 16, 153–166 (2012).
Fukawa, T. et al. Nat. Med. 22, 666–671 (2016).
Evans, W.J. et al. Clin. Nutr. 27, 793–799 (2008).
Tisdale, M.J. Future Oncol. 6, 503–513 (2010).
Blau, H.M., Cosgrove, B.D. & Ho, A.T. Nat. Med. 21, 854–862 (2015).
Bernet, J.D. et al. Nat. Med. 20, 265–271 (2014).
Kruszynska, Y.T. & Sherratt, H.S. Biochem. Pharmacol. 36, 3917–3921 (1987).
Segalés, J. et al. Skelet. Muscle 6, 9 (2016).
Brack, A.S. & Muñoz-Cánoves, P. Skelet. Muscle 6, 1 (2015).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Sassoon, D. Fatty acid metabolism—the first trigger for cachexia?. Nat Med 22, 584–585 (2016). https://doi.org/10.1038/nm.4121
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm.4121
- Springer Nature America, Inc.
This article is cited by
-
Beneficial effects of buspirone in endothelin-1 induced stroke cachexia in rats
Molecular and Cellular Biochemistry (2023)
-
Editorial: Listen to your belly, fat is not your foe!
European Journal of Nuclear Medicine and Molecular Imaging (2017)