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Closing the loop on the bone-resorbing osteoclast

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A new study shows in mice that tumor necrosis factor (TNF) superfamily member 11 (TNFSF11, also known as RANKL), which stimulates osteoclasts to remove bone, binds to the G-protein-coupled receptor LGR4 to prevent excessive bone removal. In mouse models of osteoporosis, a recombinant LGR4 ectodomain reduces bone loss.

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Figure 1: The osteoclast negative-feedback loop.

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Authors and Affiliations

  1. Mone Zaidi is in the Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA.,

    Mone Zaidi

  2. Jameel Iqbal is in the Department of Pathology, Los Angeles VA Medical Center, Los Angeles, California, USA.,

    Jameel Iqbal

Authors
  1. Mone Zaidi
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  2. Jameel Iqbal
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Correspondence to Mone Zaidi.

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Competing interests

Mone Zaidi has consulted and/or consults for Merck, Novartis, Roche, Alexion, Gershon Lehman Group and Guidepoint on issues related to osteoporosis and its treatment. A patent relating to the effects of follicle-stimulating hormone on bone has been granted, and any proceeds to the Icahn School of Medicine at Mount Sinai from licensing or royalty will be shared with Dr. Zaidi.

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Zaidi, M., Iqbal, J. Closing the loop on the bone-resorbing osteoclast. Nat Med 22, 460–461 (2016). https://doi.org/10.1038/nm.4104

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