References
LaFave, L.M. et al. Nat. Med. 21, 1344–1349 (2015).
Harbour, J.W. et al. Science 330, 1410–1413 (2010).
Margueron, R. & Reinberg, D. Nature 469, 343–349 (2011).
Amirouchene-Angelozzi, N. et al. Mol. Oncol. 8, 1508–1520 (2014).
Laurent, C. et al. Mol. Oncol. 7, 625–636 (2013).
Acknowledgements
This study was supported by INSERM grant EpiUM (M.-H.S., S.R.-R. and R.M.) and InCA grant UMCURE (M.-H.S. and S.R.-R.). The authors thank P.A. Van Der Velden (Leiden University) for kindly providing OMM1 and OMM2.5 cells.
Author information
Authors and Affiliations
Contributions
M.S. and S.L.C. performed experiments and prepared the figures; E.M. analyzed the ChIP-seq data; A.H. analyzed the transcriptomic data; M.S., M.-H.S., S.R.-R. and R.M. analyzed data and directed the study; M.S., S.R.-R. and R.M. wrote the manuscript; and all authors reviewed the manuscript and provided final approval for submission.
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Supplementary information
Supplementary Information
Supplementary Figure 1 and Supplementary Table 1 (PDF 354 kb)
Rights and permissions
About this article
Cite this article
Schoumacher, M., Le Corre, S., Houy, A. et al. Uveal melanoma cells are resistant to EZH2 inhibition regardless of BAP1 status. Nat Med 22, 577–578 (2016). https://doi.org/10.1038/nm.4098
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm.4098
- Springer Nature America, Inc.
This article is cited by
-
New targeted and epigenetic therapeutic strategies for the treatment of uveal melanoma
Cancer Gene Therapy (2022)
-
BAP1 loss augments sensitivity to BET inhibitors in cancer cells
Acta Pharmacologica Sinica (2022)
-
Clear cell renal cell carcinoma ontogeny and mechanisms of lethality
Nature Reviews Nephrology (2021)
-
Verification of EZH2 as a druggable target in metastatic uveal melanoma
Molecular Cancer (2020)
-
BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation
Nature Communications (2019)