Altered microbial colonization associated with cesarean section (C-section) birth could potentially have adverse effects on host development. The first interventional study of its kind attempts to reconfigure the early microbiota composition in C-section–delivered newborns to resemble that associated with vaginal birth.
References
Bäckhed, F. et al. Cell Host Microbe 17, 690–703 (2015).
Meropol, S.B. & Edwards, A. Birth Defects Res. C Embryo Today 4, 228–239 (2015).
Curran, E.A. et al. JAMA Psychiatry 72, 935–942 (2015).
Dominguez-Bello, M.G. et al. Nat. Med. doi:10.1038/nm.4039 (in the press).
Dominguez-Bello, M.G. et al. Proc. Natl. Acad. Sci. USA 107, 11971–11975 (2010).
Aagaard, K. et al. Sci. Transl. Med. 6, 237ra65 (2014).
World Health Organisation. Lancet 2, 436–437 (1985).
Martin, J.A. et al. Natl. Vital Stat. Rep. 60, 1–70 (2011).
Betrán, A.P. et al. Paediatr. Perinat. Epidemiol. 21, 98–113 (2007).
Arrieta, M.C. et al. Sci. Transl. Med. 7, 307ra152 (2015).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Khoruts, A. First microbial encounters. Nat Med 22, 231–232 (2016). https://doi.org/10.1038/nm.4042
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm.4042
- Springer Nature America, Inc.
This article is cited by
-
Understanding the mechanisms of faecal microbiota transplantation
Nature Reviews Gastroenterology & Hepatology (2016)