A new study in mice suggests that pharmacologically targeting the apoptosis proteins BCL-2 and BCL-xL can clear senescent cells from bone marrow and ameliorate stem cell function during aging, bringing us a step closer to preventing senescence-associated tissue attrition in the clinic.
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Geiger, H. Depleting senescent cells to combat aging. Nat Med 22, 23–24 (2016). https://doi.org/10.1038/nm.4024
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DOI: https://doi.org/10.1038/nm.4024
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