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Suppressive activity of human regulatory T cells is maintained in the presence of TNF

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Figure 1: Human Treg cell suppressive activity is not impaired in the presence of TNF.

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Acknowledgements

We thank G. Marodon for helpful discussion, M. Cherai for technical support and Y. Lombardi for statistical analyses. This work was supported by the Fondation Bettencourt Schueller and by the Association de la Recherche sur la Sclérose en Plaques.

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Author notes

  1. Xin Chen

    Present address: Present address: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China.,

Authors and Affiliations

  1. Sorbonne Universités, UPMC Univ Paris 06, INSERM, CNRS, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), 91 Bd de l'hôpital, Paris, France

    Bruno Zaragoza, Audrey Baeyens, Sylvie Gregoire, Driss Chader, Guy Gorochov, Makoto Miyara & Benoît L Salomon

  2. Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA

    Xin Chen

  3. Laboratory of Molecular Immunoregulation; Cancer Inflammation Program, Center for Cancer Research, National Cancer Institute,

    Xin Chen & Joost J Oppenheim

  4. Cancer Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA

    Xin Chen & Joost J Oppenheim

  5. Immunology Department, Assistance Publique — Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Paris, France

    Guy Gorochov & Makoto Miyara

Authors
  1. Bruno Zaragoza
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  2. Xin Chen
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  3. Joost J Oppenheim
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  4. Audrey Baeyens
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  5. Sylvie Gregoire
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  6. Driss Chader
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  7. Guy Gorochov
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  9. Benoît L Salomon
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Contributions

B.Z., X.C., J.J.O., M.M. and B.L.S. designed and discussed the initial project; B.Z., X.C., A.B., S.G., D.C., M.M. and B.L.S. performed experiments and analyzed data; G.G. gave conceptual advice; B.Z. and B.L.S. wrote the manuscript.

Corresponding author

Correspondence to Benoît L Salomon.

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The authors declare no competing financial interests.

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Supplementary Figures 1–8, Table 1 (PDF 917 kb)

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Zaragoza, B., Chen, X., Oppenheim, J. et al. Suppressive activity of human regulatory T cells is maintained in the presence of TNF. Nat Med 22, 16–17 (2016). https://doi.org/10.1038/nm.4019

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