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A new role for dystrophin in muscle stem cells

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Duchenne muscular dystrophy (DMD) is a devastating X-linked disease that is characterized by progressive muscle degeneration and caused by mutations in dystrophin. Dystrophin is critical for myofiber structural integrity, but a new study reveals an additional important role for this protein in muscle stem cells.

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Figure 1: The role of dystrophin in satellite cells in Duchenne muscular dystrophy (DMD).

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Authors and Affiliations

  1. Alexandra C. Keefe and Gabrielle Kardon are in the Department of Human Genetics, University of Utah, Salt Lake City, Utah, USA.,

    Alexandra C Keefe & Gabrielle Kardon

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  1. Alexandra C Keefe
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  2. Gabrielle Kardon
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Correspondence to Gabrielle Kardon.

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The authors declare no competing financial interests.

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Keefe, A., Kardon, G. A new role for dystrophin in muscle stem cells. Nat Med 21, 1391–1393 (2015). https://doi.org/10.1038/nm.4006

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