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Duodenal energy sensing regulates hepatic glucose output

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The maintenance of blood glucose involves the coordination of multiple organ systems. Two new studies indicate that metformin and resveratrol activate metabolic sensors in the duodenum and initiate a neural loop that reduces liver glucose production in rat models of type 2 diabetes.

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Figure 1: Proposed mechanism by which metformin and resveratrol lower hepatic glucose output.

Kim Caesar/Nature Publishing Group

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Authors and Affiliations

  1. Brennan K. Smith and Gregory R. Steinberg are in the Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.,

    Brennan K Smith & Gregory R Steinberg

  2. Gregory R. Steinberg is also in the Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.,

    Gregory R Steinberg

Authors
  1. Brennan K Smith
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  2. Gregory R Steinberg
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Correspondence to Gregory R Steinberg.

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The authors declare no competing financial interests.

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Smith, B., Steinberg, G. Duodenal energy sensing regulates hepatic glucose output. Nat Med 21, 428–429 (2015). https://doi.org/10.1038/nm.3859

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