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A B cell–dependent mechanism restrains T cell transendothelial migration

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A new study reveals that B cells restrict the transendothelial migration of T cells in physiological inflammation in response to adiponectin, but that this mechanism is compromised in autoimmunity and is hence a novel avenue for therapy development.

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Figure 1: The role of B cells in S1P-mediated regulation of T cell trafficking.

Kim Caesar/Nature Publishing Group

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Authors and Affiliations

  1. Julie D. Saba is at the Children's Hospital Oakland Research Institute, University of California, San Francisco (UCSF) Benioff Children's Hospital Oakland, Oakland, California, USA.,

    Julie D Saba

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  1. Julie D Saba
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Correspondence to Julie D Saba.

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Saba, J. A B cell–dependent mechanism restrains T cell transendothelial migration. Nat Med 21, 424–426 (2015). https://doi.org/10.1038/nm.3858

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