Skip to main content
SpringerLink
Log in

Understanding Local Macrophage Phenotypes In Disease: Shape-shifting macrophages

  • Between Bedside and Bench
  • Published:

From Nature Medicine

View current issue Submit your manuscript

Macrophages are responsive to local tissue signals and alter their phenotypes accordingly. In disease tissues this means that macrophage phenotypes may change with disease progression, exacerbating or facilitating the resolution of the pathology.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: The plasticity of macrophages.

Marina Corral Spence / Nature Publishing Group

References

  1. Murray, P.J. et al. Immunity 41, 14–20 (2014).

    Article  CAS  Google Scholar 

  2. Davies, L.C., Jenkins, S.J., Allen, J.E. & Taylor, P.R. Nat. Immunol. 14, 986–995 (2013).

    Article  CAS  Google Scholar 

  3. Okabe, Y. & Medzhitov, R. Cell 157, 832–844 (2014).

    Article  CAS  Google Scholar 

  4. Rosas, M. et al. Science 344, 645–648 (2014).

    Article  CAS  Google Scholar 

  5. Gosselin, D. et al. Cell 159, 1327–1340 (2014).

    Article  CAS  Google Scholar 

  6. Lavin, Y. et al. Cell 159, 1312–1326 (2014).

    Article  CAS  Google Scholar 

  7. Qian, B.Z. & Pollard, J.W. Cell 141, 39–51 (2010).

    Article  CAS  Google Scholar 

  8. Sica, A. & Mantovani, A. J. Clin. Invest. 122, 787–795 (2012).

    Article  CAS  Google Scholar 

  9. Lewis, C.E. & Pollard, J.W. Cancer Res. 66, 605–612 (2006).

    Article  CAS  Google Scholar 

  10. Movahedi, K. et al. Cancer Res. 70, 5728–5739 (2010).

    Article  CAS  Google Scholar 

  11. Franklin, R.A. et al. Science 344, 921–925 (2014).

    Article  CAS  Google Scholar 

  12. Wang, Y.C. et al. Cancer Res. 70, 4840–4849 (2010).

    Article  CAS  Google Scholar 

  13. Chittezhath, M. et al. Immunity 41, 815–829 (2014).

    Article  CAS  Google Scholar 

  14. Misharin, A.V. et al. Cell Rep. 9, 591–604 (2014).

    Article  CAS  Google Scholar 

  15. Courties, G. et al. J. Am. Coll. Cardiol. 63, 1556–1566 (2014).

    Article  CAS  Google Scholar 

  16. Hoeksema, M.A. et al. EMBO Mol. Med. 6, 1124–1132 (2014).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Kate Liddiard is at the Institute of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK.,

    Kate Liddiard

  2. Philip R. Taylor is at the Cardiff Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.,

    Philip R Taylor

Authors
  1. Kate Liddiard
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Philip R Taylor
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Philip R Taylor.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Liddiard, K., Taylor, P. Understanding Local Macrophage Phenotypes In Disease: Shape-shifting macrophages. Nat Med 21, 119–120 (2015). https://doi.org/10.1038/nm.3798

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm.3798

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation