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Reducing peripheral serotonin turns up the heat in brown fat

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Obesity is a major risk factor for chronic disease. A new study in mice reveals that lowering levels of the signaling molecule serotonin outside of the brain reduces obesity and its complications by increasing brown adipose tissue (BAT) energy expenditure.

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Figure 1: Inhibition of peripheral serotonin production protects from diet-induced obesity and related complications.

Marina Corral Spence/Nature Publishing Group

References

  1. Turner, N. et al. Diabetologia 56, 1638–1648 (2013).

    Article  CAS  Google Scholar 

  2. Carey, A.L. & Kingwell, B.A. Pharmacol. Ther. 140, 26–33 (2013).

    Article  CAS  Google Scholar 

  3. Tecott, L.H. Cell Metab. 6, 352–361 (2007).

    Article  CAS  Google Scholar 

  4. Madden, C.J. & Morrison, S.F. Am. J. Physiol. Regul. Integr. Comp. Physiol. 298, R776–R783 (2010).

    Article  CAS  Google Scholar 

  5. Gershon, M.D. Curr. Opin. Endocrinol. Diabetes Obes. 20, 14–21 (2013).

    Article  CAS  Google Scholar 

  6. Crane, J.D. et al. Nat. Med. 21, 166–172 (2015).

    Article  CAS  Google Scholar 

  7. Yadav, V.K. et al. Nat. Med. 16, 308–312 (2010).

    Article  CAS  Google Scholar 

  8. Nedergaard, J. & Cannon, B. Cell Metab. 20, 396–407 (2014).

    Article  CAS  Google Scholar 

  9. Carey, A.L. et al. Diabetologia 56, 147–155 (2013).

    Article  CAS  Google Scholar 

  10. Allen, N.C. et al. Nat. Genet. 40, 827–834 (2008).

    Article  CAS  Google Scholar 

  11. Liu, X. et al. J. Med. Genet. 43, e4 (2006).

    Article  CAS  Google Scholar 

  12. Zill, P. et al. Neurosci. 159, 1274–1282 (2009).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Andrew L. Carey and Bronwyn A. Kingwell are in the Metabolic and Vascular Physiology Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Australia.,

    Andrew L Carey & Bronwyn A Kingwell

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  1. Andrew L Carey
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  2. Bronwyn A Kingwell
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Correspondence to Bronwyn A Kingwell.

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The authors declare no competing financial interests.

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Carey, A., Kingwell, B. Reducing peripheral serotonin turns up the heat in brown fat. Nat Med 21, 114–116 (2015). https://doi.org/10.1038/nm.3797

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