Preosteoclasts give rise to bone-resorbing osteoclasts, which are crucial for skeletal homeostasis. A study now shows that preosteoclasts also contribute to bone formation by releasing platelet-derived growth factor-BB, which promotes bone vascularization and osteogenesis.
References
Maes, C. et al. Dev. Cell 19, 329–344 (2010).
Kusumbe, A.P., Ramasamy, S.K. & Adams, R.H. Nature 507, 323–328 (2014).
Ramasamy, S.K., Kusumbe, A.P., Wang, L. & Adams, R.H. Nature 507, 376–380 (2014).
Xie, H. et al. Nat. Med. 20, 1270–1278 (2014).
Kreja, L. et al. J. Cell. Biochem. 109, 347–355 (2010).
Sanchez-Fernandez, M.A. et al. PLoS ONE 3, e3537 (2008).
Andrae, J., Gallini, R. & Betsholtz, C. Genes Dev. 22, 1276–1312 (2008).
Ball, S.G., Shuttleworth, C.A. & Kielty, C.M. J. Cell. Mol. Med. 11, 1012–1030 (2007).
Olsson, A.K. Dimberg, A., Kreuger, J. & Claesson-Welsh, L. Nat. Rev. Mol. Cell Biol. 7, 359–371 (2006).
Richardson, M.R. & Yoder, M.C. 50, 266–272 (2011).
Mendelson, K., Evans, T. & Hla, T. Development 141, 5–9 (2014).
Ryu, J. et al. EMBO J. 25, 5840–5851 (2006).
Saftig, P. et al. Proc. Natl. Acad. Sci. USA 95, 13453–13458 (1998).
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Kusumbe, A., Adams, R. Osteoclast progenitors promote bone vascularization and osteogenesis. Nat Med 20, 1238–1240 (2014). https://doi.org/10.1038/nm.3747
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DOI: https://doi.org/10.1038/nm.3747
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