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Fatty acid synthesis tips the TH17-Treg cell balance

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A recent study reports that de novo fatty acid synthesis is important for differentiation of T helper 17 (TH17) cells. Suppression of this pathway through inhibition of acetyl-CoA carboxylase (ACC) with soraphen A prevents TH17 cell differentiation and consequently enforces a regulatory T cell phenotype.

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Figure 1: Induction of the Treg phenotype by inhibition of ACC1.

Katie Vicari/Nature Publishing Group

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Authors and Affiliations

  1. David O'Sullivan and Erika L. Pearce are at the Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.,

    David O'Sullivan & Erika L. Pearce

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  1. David O'Sullivan
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  2. Erika L. Pearce
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Correspondence to Erika L. Pearce.

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The authors declare no competing financial interests.

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O'Sullivan, D., Pearce, E. Fatty acid synthesis tips the TH17-Treg cell balance. Nat Med 20, 1235–1236 (2014). https://doi.org/10.1038/nm.3744

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