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Understanding the role of progranulin in Alzheimer's disease

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Alzheimer's disease is characterized by severe cognitive decline and brain amyloid plaques. A new study in mouse models that develop features of Alzheimer's disease indicates that progranulin may have a role in clearing these plaques.

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Figure 1: The role of progranulin in amyloid plaque formation.

Katie Vicari/Nature Publishing Group

References

  1. Fargo, K. & Bleiler, L. Alzheimers Dement. 10, e47–e92 (2014).

    Article  Google Scholar 

  2. Schneider, L.S. et al. J. Intern. Med. 275, 251–283 (2014).

    Article  CAS  Google Scholar 

  3. Baker, M. et al. Nature 442, 916–919 (2006).

    Article  CAS  Google Scholar 

  4. Cruts, M. et al. Nature 442, 920–924 (2006).

    Article  CAS  Google Scholar 

  5. Petkau, T.L. & Leavitt, B.R. Trends Neurosci. 37, 388–398 (2014).

    Article  CAS  Google Scholar 

  6. Sheng, J., Su, L., Xu, Z. & Chen, G. Gene 542, 141–145 (2014).

    Article  CAS  Google Scholar 

  7. Minami, S.S. et al. Nat. Med. 20, 1157–1164 (2014).

    Article  CAS  Google Scholar 

  8. Pereson, S. et al. J. Pathol. 219, 173–181 (2009).

    Article  CAS  Google Scholar 

  9. Lucin, K.M. et al. Neuron 79, 873–886 (2013).

    Article  CAS  Google Scholar 

  10. Kim, W.S. et al. J. Neurosci. 33, 4387–4394 (2013).

    Article  CAS  Google Scholar 

  11. Karch, C.M. & Goate, A.M. Biol. Psychiatry. doi:10.1016/j.biopsych.2014.05.006 (17 May 2014).

  12. Boxer, A.L. et al. Alzheimers Dement. 9, 176–188 (2013).

    Article  Google Scholar 

  13. Toh, H., Chitramuthu, B.P., Bennett, H.P. & Bateman, A. J. Mol. Neurosci. 45, 538–548 (2011).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Neuroscience, Simon D'Alton and Jada Lewis are at the Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, Florida, USA.,

    Simon D'Alton & Jada Lewis

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  1. Simon D'Alton
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  2. Jada Lewis
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Correspondence to Jada Lewis.

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The authors declare no competing financial interests.

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D'Alton, S., Lewis, J. Understanding the role of progranulin in Alzheimer's disease. Nat Med 20, 1099–1100 (2014). https://doi.org/10.1038/nm.3712

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