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Inhibiting Janus kinases to treat alopecia areata

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Alopecia areata is an immune-mediated, nonscarring form of hair loss. A new study using human clinical samples and a mouse model demonstrates that CD8αβ+NKG2D+ T effector memory cells mediate alopecia areata in part through Janus kinase (JAK) signaling and that alopecia areata might be treated with JAK inhibitors.

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Figure 1: Positive feedback loop in AA.

Debbie Maizels/Nature Publishing Group

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Authors and Affiliations

  1. Sherrie J. Divito and Thomas S. Kupper are at the Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.,

    Sherrie J Divito & Thomas S Kupper

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  1. Sherrie J Divito
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  2. Thomas S Kupper
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Correspondence to Thomas S Kupper.

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Divito, S., Kupper, T. Inhibiting Janus kinases to treat alopecia areata. Nat Med 20, 989–990 (2014). https://doi.org/10.1038/nm.3685

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