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Rejuvenating aged muscle stem cells

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Decreased muscle stem cell function in aging has long been shown to depend on altered environmental cues, whereas the contribution of intrinsic mechanisms remained less clear. Two new studies now reveal that cell-autonomous changes in the p38 mitogen-activated protein kinase pathway are major phenotype determinants of aged muscles stem cells (pages 255–271).

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Figure 1: Increased p38 signaling impairs self-renewal of aged satellite cells.

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Authors and Affiliations

  1. Department of Cellular and Molecular Medicine, C. Florian Bentzinger and Michael A. Rudnicki are in the Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada, and in the Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.,

    C Florian Bentzinger & Michael A Rudnicki

  2. Michael A. Rudnicki is also at the Sprott Center for Stem Cell Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.,

    Michael A Rudnicki

Authors
  1. C Florian Bentzinger
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  2. Michael A Rudnicki
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Correspondence to Michael A Rudnicki.

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The authors declare no competing financial interests.

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Bentzinger, C., Rudnicki, M. Rejuvenating aged muscle stem cells. Nat Med 20, 234–235 (2014). https://doi.org/10.1038/nm.3499

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