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Drug-resistant tuberculosis: a new shot on goal

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Modification of a natural product with antibiotic properties to block its efflux from Mycobacterium tuberculosis results in a new drug candidate for tuberculosis with a promising therapeutic profile in mice (pages 152–158).

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Figure 1: Mtb is susceptible to semisynthetic spectinamides but not to spectinomycin, the natural product from which spectinamides are derived.

Marina Corral Spence

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Authors and Affiliations

  1. Carl Nathan is at the Department of Microbiology and Immunology, Weill Cornell Medical College, and the Program in Immunology and Microbial Pathogenesis, Weill Graduate School of Medical Sciences of Cornell University, New York, New York, USA.,

    Carl Nathan

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  1. Carl Nathan
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Correspondence to Carl Nathan.

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Nathan, C. Drug-resistant tuberculosis: a new shot on goal. Nat Med 20, 121–123 (2014). https://doi.org/10.1038/nm.3470

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