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Striking a balance in fragile X

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In fragile X syndrome, the absence of fragile X mental retardation protein (FMRP) allows the production of certain proteins to go unchecked in the brain. A recent study in mice suggests that bringing excessive translation into balance may provide a key to treating this syndrome (pages 1473–1477).

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Figure 1: A model for the functional relationship between FMRP and CPEB in the regulation of protein synthesis.

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Authors and Affiliations

  1. Laura N. Smith and Christopher W. Cowan are at the Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA.,

    Laura N Smith & Christopher W Cowan

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  1. Laura N Smith
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  2. Christopher W Cowan
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Correspondence to Christopher W Cowan.

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The authors declare no competing financial interests.

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Smith, L., Cowan, C. Striking a balance in fragile X. Nat Med 19, 1370–1371 (2013). https://doi.org/10.1038/nm.3383

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